Babesia rodhaini: Carbohydrate metabolism and infectivity for rats of cells freed from host erythrocytes

Rickard M.D. (1970) Babesia rodhaini: Carbohydrate metabolism and infectivity for rats of cells freed from host erythrocytes. Experimental Parasitology, 27 1: 136-142.

Author Rickard M.D.
Title Babesia rodhaini: Carbohydrate metabolism and infectivity for rats of cells freed from host erythrocytes
Journal name Experimental Parasitology   Check publisher's open access policy
ISSN 0014-4894
Publication date 1970
Sub-type Article (original research)
Volume 27
Issue 1
Start page 136
End page 142
Total pages 7
Subject 2725 Infectious Diseases
2405 Parasitology
2403 Immunology
Abstract When Babesia rodhaini-infected erythrocytes are injected into the peritoneal cavity of rats, they pass quickly into the peripheral circulation. Parasites freed from their host cells with hemolytic antiserum are not infective by this route of inoculation; however, they are infective after intravenous injection, although the delayed development of infection suggests that few of the parasites are capable of infecting new erythrocytes at the time of their artificial release from the host cell. Although freed B. rodhaini is still metabolically active, and therefore appears to possess its own complement of glycolytic enzymes, it is not so competent as those within intact erythrocytes. It is suggested that parasites may influence the metabolism of the host cell to their own advantage. Addition of co-factors to the incubation medium improves the metabolic performance of freed parasites, and indicates a relatively high permeability of the parasite's cell membrane. This is of obvious advantage to an intracellular organism. B. rodhaini is able to utilize a wide range of substrates but is limited to some extent, when within its host cell, by the differential permeability of the erythrocyte membrane. The lack of metabolic products when parasites are incubated without added substrate suggests that this organism does not store any quantity of endogenous substrate within itself.
Keyword Alanine
Amino acids
Babesia rodhaini
Co-factors
Erythrocytes
Galactose
Glucose
Glutamic acid
Glycerol
Lactate
Lactose
Maltose
Metabolism
Oxygen uptake
Pyruvate
Sucrose
Sugars
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 12 Jul 2016, 03:53:19 EST by System User