Effects of chronic ethanol treatment and aging on brain phosphoinositide turnover and adenylate cyclase activity

Pietrzak E.R., Wilce P.A. and Shanley B.C. (1990) Effects of chronic ethanol treatment and aging on brain phosphoinositide turnover and adenylate cyclase activity. Neurochemistry International, 17 4: 593-598. doi:10.1016/0197-0186(90)90047-W


Author Pietrzak E.R.
Wilce P.A.
Shanley B.C.
Title Effects of chronic ethanol treatment and aging on brain phosphoinositide turnover and adenylate cyclase activity
Journal name Neurochemistry International   Check publisher's open access policy
ISSN 0197-0186
Publication date 1990-01-01
Sub-type Article (original research)
DOI 10.1016/0197-0186(90)90047-W
Volume 17
Issue 4
Start page 593
End page 598
Total pages 6
Subject 1307 Cell Biology
1312 Molecular Biology
2804 Cellular and Molecular Neuroscience
Abstract Inositol phosphate accumulation and adenylate cyclase activity were investigated in the cortex of young and aged ethanol-treated rats. Three months of ethanol treatment of young rats decreased maximal stimulation of inositol phosphate accumulation by carbachol by 26%, from 494 ± 76% of basal turnover in control animals to 396 ± 54% in ethanol-treated animals (mean ± SD). In aged rats ethanol-related changes were no longer observed but age-related changes were evident. EC50 was significantly higher than in young animals and maximal stimulation was significantly lower. Basal adenylate cyclase activity in cortical membranes of all groups of animals was not different. Forskolin-stimulated adenylate cyclase activity was not affected by ethanol treatment, but was higher in aged animals. The activity of forskolin-stimulated adenylate cyclase in the presence of carbachol was higher in both young and aged ethanol-treated animals, when compared to young controls. These results suggest that both ethanol and aging impair the efficiency of receptor/effector coupling.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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