Interactions of substance P with putative mediators of inflammation and ATP

Chahl L.A. (1977) Interactions of substance P with putative mediators of inflammation and ATP. European Journal of Pharmacology, 44 1: 45-49. doi:10.1016/0014-2999(77)90114-5


Author Chahl L.A.
Title Interactions of substance P with putative mediators of inflammation and ATP
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1977-07-01
Sub-type Article (original research)
DOI 10.1016/0014-2999(77)90114-5
Volume 44
Issue 1
Start page 45
End page 49
Total pages 5
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract Substance P has recently been localized in sensory nerves and has been suggested to be the mediator of antidromic vasodilatation. Interactions of substance P with putative mediators of inflamation and adenosine 5′-triphosphate were studied in rats using a quantitative Evans blue dye-leakage technique. Rats anaesthetized with ether were given Evans blue i.v. and intracutaneous injections of inflammatory agents were given into the shaved abdominal skin. Doses of substance P, 1-5 × 10-10 mol, produced graded dye leakage. A low dose of substance P (5 × 10-11 mol) potentiated responses to 5-hydroxytryptamine (2.5 × 10-10 mol), bradykinin (5 × 10-10 mol), prostaglandin E1 (5 × 10-10 mol) and adenosine 5′-triphosphate (2.5 × 10-7 mol) but not histamine (2 × 10-8 mol). A higher dose of substance P (5 × 10-10 mol) was potentiated by prostaglandin E1 (5 × 10-11 mol) and adenosine 5′-triphosphate (5 × 10-9 mol) but not by histamine (5 × 10-10 mol) or bradykinin (5 × 10-11 mol) and was inhibited by 5-hydroxytryptamine (5 × 10-12 mol). If substance P is released from sensory nerves in some inflammatory states these interactions might be of importance in determining the response observed.
Keyword ATP
Inflammatory mediators
Substance P
Vascular permeability
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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