Genetic control of liability to infection with Nematospiroides dubius in mice: Selection of refractory and liable populations of mice

Brindley P.J. and Dobson C. (1981) Genetic control of liability to infection with Nematospiroides dubius in mice: Selection of refractory and liable populations of mice. Parasitology, 83 1: 51-65. doi:10.1017/S0031182000050034


Author Brindley P.J.
Dobson C.
Title Genetic control of liability to infection with Nematospiroides dubius in mice: Selection of refractory and liable populations of mice
Journal name Parasitology   Check publisher's open access policy
ISSN 1469-8161
Publication date 1981
Sub-type Article (original research)
DOI 10.1017/S0031182000050034
Volume 83
Issue 1
Start page 51
End page 65
Total pages 15
Subject 2405 Parasitology
2725 Infectious Diseases
1103 Clinical Sciences
2403 Immunology
Abstract Quackenbush strain and wild Mus musculus were assayed for their liability to primary infection with 100 L3 Nematospiroides dubius using an experimentally derived selection index. Refractory and liable colonies of mice were established over 5 generations. Liability to N. dubius infection was found likely to be controlled by several genes; the heritability (h2) of this trait was estimated at 0–45. Positive linear correlation was found between the number of parasite eggs voided and the number of adult N. dubius recovered, negative correlation between the pre-patent period of infection in days and the number of parasite eggs voided and positive correlation in 2 of 5 generations between live mouse body weight and the number of adult N. dubius recovered. Further, positive correlation was found between the liability of female mice to N. dubius and their progeny litter size number. The genetic mechanisms controlling the liability trait and the possible evolutionary significance of these results are discussed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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