The role of the rumen in absorption of Lantana toxins in sheep

McSweeney C.S. and Pass M.A. (1983) The role of the rumen in absorption of Lantana toxins in sheep. Toxicon, 21 SUPPL. 3: 285-288. doi:10.1016/0041-0101(83)90210-6


Author McSweeney C.S.
Pass M.A.
Title The role of the rumen in absorption of Lantana toxins in sheep
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1983
Sub-type Article (original research)
DOI 10.1016/0041-0101(83)90210-6
Volume 21
Issue SUPPL. 3
Start page 285
End page 288
Total pages 4
Subject 3005 Toxicology
Abstract Absorption of the toxins of Lantana camara L. was studied by infusing a suspension of lantana into segments of the alimentary tract which had been isolated between intestinal cannulae. The severity of intoxication was used to estimate the extent of absorption. It was found that the toxins were absorbed most readily from the small intestine but considerable amounts were also absorbed from the stomachs and large intestine. When rumen contents were collected from intoxicated sheep up to 6 days after lantana was given and administered to normal sheep, the recipient animals become intoxicated and the donor animals recovered. This indicates that a large proportion of the administered dose of toxin is retained in the rumen and that continuous absorption of the toxins is necessary to maintain the disease. Experiments on rumen motility demonstrated that rumen stasis occurs within a few hours of administering lantana and there is a corresponding decrease in the flow of ingesta into the small intestine. It is concluded that large amounts of toxins are retained in the static rumen of lantana intoxicated sheep and this provides a reservoir of toxins from which continuous absorption maintains the disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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