The effect of female sex hormone supplementation on tendon in pre and postmenopausal women: a systematic review

Ganderton, C., Semciw, A., Cook, J. and Pizzari, T. (2016) The effect of female sex hormone supplementation on tendon in pre and postmenopausal women: a systematic review. The Journal of Musculoskeletal and Neuronal Interactions, 16 2: 92-104.

Author Ganderton, C.
Semciw, A.
Cook, J.
Pizzari, T.
Title The effect of female sex hormone supplementation on tendon in pre and postmenopausal women: a systematic review
Journal name The Journal of Musculoskeletal and Neuronal Interactions   Check publisher's open access policy
ISSN 1108-7161
Publication date 2016-06-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
Open Access Status Not Open Access
Volume 16
Issue 2
Start page 92
End page 104
Total pages 13
Place of publication Nafplion, Greece
Publisher International Society of Musculoskeletal and Neuronal Interactions
Collection year 2017
Language eng
Formatted abstract
Objectives: Oestrogen deprivation has been shown to have a negative effect on connective tissue and its turnover. A link may exist between supplemental oestrogen, preservation of tendon collagen and less tendon abnormality. The aim was to determine the effects of female sex hormone supplementation (FSHS) on tendon.

Methods: A systematic search of nine key health databases; Medline, CINAHL, EMBASE, SPORTDiscus, AUSPORT and AMI, Cochrane Library, SafetyLit and PEDro was completed (to Feb 24, 2016). The search yielded 6378 records using terms relating to hormone (oestrogen, estrogen, hormone replacement therapy, HRT, estrogen therapy, oestrogen therapy, oral contraceptive pill) and tendon. Quality assessment, data extraction and data synthesis of included papers was undertaken.

Results: Low level of evidence for all outcomes; no positive or negative link between FSHS and molecular, mechanical and morphological tendon response outcomes, and the addition of exercise to FSHS, had minimal effects on tendon CSA.

Conclusions: The effect of oestrogen supplementation on tendon is contradictory and inconsistent. This review suggests there is a need for further studies to understand the effects of FSHS on tendon tissue at a mechanical, morphological and molecular level
Keyword Hormone Replacement Therapy
Oestrogen
Oral Contraceptive Pill
Women
Tendon
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Health and Rehabilitation Sciences Publications
 
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