Telomerase in hematologic malignancies

Bruedigam, Claudia and Lane, Steven W. (2016) Telomerase in hematologic malignancies. Current Opinion in Hematology, 23 4: 346-353. doi:10.1097/MOH.0000000000000252


Author Bruedigam, Claudia
Lane, Steven W.
Title Telomerase in hematologic malignancies
Journal name Current Opinion in Hematology   Check publisher's open access policy
ISSN 1531-7048
1065-6251
1080-8213
Publication date 2016-07-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MOH.0000000000000252
Open Access Status Not Open Access
Volume 23
Issue 4
Start page 346
End page 353
Total pages 8
Place of publication London, United Kingdom
Publisher Lippincott Williams and Wilkins
Collection year 2017
Language eng
Formatted abstract
Purpose of review: The activation of telomere maintenance pathways has long been regarded as a key hallmark of cancer and this has propelled the development of novel inhibitors of telomerase. In this review, we detail the background biology on telomere maintenance in health and disease, then concentrate on the recent preclinical and clinical development behind targeting telomerase in blood cancers.

Recent findings: Preclinical and clinical studies have shown that imetelstat, a competitive inhibitor of telomerase, has activity in certain hematologic malignancies, in particular the myeloproliferative neoplasms and acute myeloid leukemia.

Summary: Telomerase inhibition has shown remarkable efficacy in myeloid malignancies, and current and future preclinical and clinical studies are necessary to comprehensively investigate its underlying mechanism of action. Future work should identify the potential genetic susceptibilities to telomerase inhibition therapy, and evaluate rational combinations of telomerase inhibitors with chemotherapy and other novel agents. Robust preclinical evaluation is essential to best translate these new agents successfully into our clinical treatment algorithm for myeloid and other blood cancers.
Keyword Acute myeloid leukemia
Imetelstat
Myeloid malignancies
Telomerase
Telomere
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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