An in vitro analysis of the effect of acidosis on coagulation in chronic disease states - a thromboelastograph study

White, Hayden, Bird, Robert, Sosnowski, Kellie and Jones, Mark (2016) An in vitro analysis of the effect of acidosis on coagulation in chronic disease states - a thromboelastograph study. Clinical Medicine, 16 3: 230-234. doi:10.7861/clinmedicine.16-3-230

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Author White, Hayden
Bird, Robert
Sosnowski, Kellie
Jones, Mark
Title An in vitro analysis of the effect of acidosis on coagulation in chronic disease states - a thromboelastograph study
Journal name Clinical Medicine   Check publisher's open access policy
ISSN 1470-2118
1473-4893
Publication date 2016-06-01
Sub-type Article (original research)
DOI 10.7861/clinmedicine.16-3-230
Open Access Status File (Publisher version)
Volume 16
Issue 3
Start page 230
End page 234
Total pages 5
Place of publication London, United Kingdom
Publisher Royal College of Physicians
Collection year 2017
Language eng
Abstract Thrombosis is a complication of many chronic illnesses. Chronic obstructive pulmonary disease (COPD) and diabetes mellitus are common medical conditions frequently associated with a hypercoagulable state. Acidaemia has been shown to reduce coagulation. COPD and diabetes mellitus during acute deterioration can present with a severe acidaemia. The impact of this acidaemia on coagulation is poorly studied. Patients presenting with a diagnosis of diabetic ketoacidosis or type II respiratory failure from COPD and a pH of less than 7.2 were included in our study. A coagulation screen and a thromboelastograph (TEG) were performed on admission and 24 hours later. The mean pH on admission was 7.07 and mean base excess was –16.3. The activated partial thromboplastin time was associated with pH change but remained within the normal range (26–41 s). All other coagulation and TEG parameters failed to show evidence of association (p>0.05). In the two models of non-haemorrhagic acidosis investigated, coagulation was not altered by the changes in pH. More work is needed to understand the complex relationship between factors affecting coagulation in individual disease processes.
Keyword TEG
ROTEM
Coagulation
Acidosis
COPD
DKA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Public Health Publications
 
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