Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease

Thaysen-Andersen, Morten, Packer, Nicolle H. and Schulz, Benjamin L. (2016) Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease. Molecular and Cellular Proteomics, 15 6: 1773-1790. doi:10.1074/mcp.O115.057638


Author Thaysen-Andersen, Morten
Packer, Nicolle H.
Schulz, Benjamin L.
Title Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease
Formatted title
Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease
Journal name Molecular and Cellular Proteomics   Check publisher's open access policy
ISSN 1535-9484
1535-9476
Publication date 2016-06-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1074/mcp.O115.057638
Open Access Status Not Open Access
Volume 15
Issue 6
Start page 1773
End page 1790
Total pages 18
Place of publication Rockville, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2017
Language eng
Formatted abstract
The glycoproteome remains severely understudied because of significant analytical challenges associated with glycoproteomics, the system-wide analysis of intact glycopeptides. This review introduces important structural aspects of protein N-glycosylation and summarizes the latest technological developments and applications in LC-MS/MS-based qualitative and quantitative N-glycoproteomics. These maturing technologies provide unique structural insights into the N-glycoproteome and its synthesis and regulation by complementing existing methods in glycoscience. Modern glycoproteomics is now sufficiently mature to initiate efforts to capture the molecular complexity displayed by the N-glycoproteome, opening exciting opportunities to increase our understanding of the functional roles of protein N-glycosylation in human health and disease.
Keyword N-glycoproteome
N-glycoproteomics
Glycoscience
Human health and disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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