Bioreactors for haematopoietic cell culture

Nielsen L.K. (1999) Bioreactors for haematopoietic cell culture. Annual Review of Biomedical Engineering, 1: 129-152.

Author Nielsen L.K.
Title Bioreactors for haematopoietic cell culture
Journal name Annual Review of Biomedical Engineering   Check publisher's open access policy
ISSN 1523-9829
Publication date 1999
Sub-type Article (original research)
Issue 1
Start page 129
End page 152
Total pages 24
Subject 1304 Biophysics
2204 Religion and Religious Studies
Abstract Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, is an enabling technology with many potential applications in bone-marrow transplantation, immunotherapy, gene therapy, and the production of blood products. Hematopoietic cultures are complex, with many different cell types at different stages of development present at any given point in time and never in steady state. Moreover, these cells interact strongly with each other and the environment through cytokines (growth factors) and adhesion molecules, as well as through their metabolism. Despite these significant challenges, cell products produced in bioreactors have shown promise in recent phase 1 clinical trials. Copyright
Keyword CD34
Ex vivo expansion
Hematopoiesis
Perfusion
Stirred culture
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Sat, 09 Jul 2016, 05:28:49 EST by System User