Childhood T-cell lymphoblastic lymphoma–does early resolution of mediastinal mass predict for final outcome?

Shepherd, SF, Ahern, RP and Pinkerton, CR (1995) Childhood T-cell lymphoblastic lymphoma–does early resolution of mediastinal mass predict for final outcome?. British Journal of Cancer, 72 3: 752-756. doi:10.1038/bjc.1995.405


Author Shepherd, SF
Ahern, RP
Pinkerton, CR
Title Childhood T-cell lymphoblastic lymphoma–does early resolution of mediastinal mass predict for final outcome?
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 1532-1827
Publication date 1995
Sub-type Article (original research)
DOI 10.1038/bjc.1995.405
Volume 72
Issue 3
Start page 752
End page 756
Total pages 5
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract This study presents a retrospective review of chest radiography in children with Murphy stage III T-cell lymphoblastic lymphoma. All received a standard leukaemia-based protocol with intensive induction, consolidation and continuing chemotherapy. Neither initial thoracic disease bulk nor the presence of a pleural effusion predicted outcome. However a significant difference was found when the 50 patients in whom the chest radiograph returned to normal within 60 days of commencing treatment were compared with the 18 patients with persistent mediastinal abnormalities, for both event-free [hazard ratio ≪ or = 60 days to > 60 days (HR) 3.55 (95% CI 1.33-9.48); P = 0.007] and overall survival [HR 2.95 (95% CI 1.07-8.18); P = 0.03]. It appears that this relatively simple estimate of chemosensitivity may identify a group of particularly good-risk patients in whom drugs associated with late morbidity such as anthracyclines may be reduced and conversely a higher risk group in whom further intensification of treatment would be justified.
Keyword Chest radiography
Childhood T-cell lymphoblastic lymphoma
Resolution of mediastinal mass
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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