Progressive dysgraphia in a case of posterior cortical atrophy

O'Dowd, B. S. and de Zubicaray, G. I. (2003) Progressive dysgraphia in a case of posterior cortical atrophy. Neurocase, 9 3: 251-260. doi:10.1076/neur.9.3.251.15561


Author O'Dowd, B. S.
de Zubicaray, G. I.
Title Progressive dysgraphia in a case of posterior cortical atrophy
Journal name Neurocase   Check publisher's open access policy
ISSN 1355-4794
Publication date 2003
Sub-type Article (original research)
DOI 10.1076/neur.9.3.251.15561
Volume 9
Issue 3
Start page 251
End page 260
Total pages 10
Place of publication Lisse
Publisher Swets Zeitlinger Publishers
Collection year 2003
Language eng
Subject C1
320705 Sensory Systems
730104 Nervous system and disorders
Abstract Dysgraphia (agraphia) is a common feature of posterior cortical atrophy (PCA). However, detailed analyses of these spelling and writing impairments are infrequently conducted. LM is a 59-year-old woman with dysgraphia associated with PCA. She presented with a two-year history of decline in her writing and dressmaking skills. A 3D T-1-weighted MRI scan confirmed selective bi-parietal atrophy, with relative sparing of the hippocampi and other cortical regions. Analyses of LM's preserved and impaired spelling abilities indicated mild physical letter distortions and a significant spelling deficit characterised by letter substitutions, insertions, omissions, and transpositions that was systematically sensitive to word length while insensitive to real word versus nonword category, word frequency, regularity, imagery, grammatical class and ambiguity. Our findings suggest a primary graphemic buffer disorder underlies LM's spelling errors, possibly originating from disruption to the operation of a fronto-parietal network implicated in verbal working memory.
Keyword Clinical Neurology
Psychiatry
Psychology
Posterior Cortical Atrophy
Central And Peripheral Dysgraphia
Graphemic Output Buffer
Cognitive Spelling Models
Verbal Working-memory
Alzheimers-disease
Graphemic Buffer
Acquired Dysgraphia
Writing Impairment
Ideomotor Apraxia
Lexical Agraphia
Functional Mri
Dementia
Cortex
Q-Index Code C1

 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 13 Aug 2007, 13:43:02 EST