High-dose rapid schedule chemotherapy for disseminated neuroblastoma

Pearson, Adj, Craft, AW, Pinkerton, CR, Meller, ST and Reid, MM (1992) High-dose rapid schedule chemotherapy for disseminated neuroblastoma. European Journal of Cancer, 28 10: 1654-1659. doi:10.1016/0959-8049(92)90062-7

Author Pearson, Adj
Craft, AW
Pinkerton, CR
Meller, ST
Reid, MM
Title High-dose rapid schedule chemotherapy for disseminated neuroblastoma
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 1992
Sub-type Article (original research)
DOI 10.1016/0959-8049(92)90062-7
Volume 28
Issue 10
Start page 1654
End page 1659
Total pages 6
Language eng
Subject 1306 Cancer Research
2720 Hematology
2730 Oncology
Abstract In a high-dose schedule for disseminated neuroblastoma, eight courses of chemotherapy were administered every 10 days, regardless of myelosuppression, to eradicate tumour cells rapidly and reduce emergence of drugresistant clones. Relatively non-myelotoxic vincristine and cisplatin were alternated with high-dose cisplatin-etoposide and cyclophosphamide-etoposide. Of 12 evaluable patients, there were 1 complete (CR), 3 very good partial (VGPR), 5 partial (PR) and 3 mixed responses (MR) 100 days after starting treatment. 6 out of 9 achieved a bone marrow CR at 40 days. 9 of 11 primary tumours were completely resected, after which 4 patients had CR, 3 VGPR (bone scan alone being abnormal), 4 PR and 1 mixed response (MR). Myelotoxicity was the major adverse effect. The only death was due to fungal infection. Clinically important renal dysfunction occurred in 3 patients. 4 had convulsions and 4 temporary hypertension. This schedule produced a rapid response and its toxicity, though serious, was manageable. Further evaluation is warranted.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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