The effect of ethanol on the lipoprotein metabolism of aortic smooth muscle cells

Ruczkal-Pietrzak E., Wilce P.A. and Shanley B.C. (1986) The effect of ethanol on the lipoprotein metabolism of aortic smooth muscle cells. International Journal of Biochemistry, 18 11: 1039-1044. doi:10.1016/0020-711X(86)90250-8


Author Ruczkal-Pietrzak E.
Wilce P.A.
Shanley B.C.
Title The effect of ethanol on the lipoprotein metabolism of aortic smooth muscle cells
Journal name International Journal of Biochemistry   Check publisher's open access policy
ISSN 0020-711X
Publication date 1986
Sub-type Article (original research)
DOI 10.1016/0020-711X(86)90250-8
Volume 18
Issue 11
Start page 1039
End page 1044
Total pages 6
Subject 1303 Specialist Studies in Education
Abstract 1. 1. The effect of ethanol exposure on the binding and metabolism of bovine low density lipoprotein by bovine arterial smooth muscle cells was studied. 2. 2. In cells exposed to ethanol (80 mM) for 48 hr or 14 days and incubated with low density lipoprotein for 24 hr there was a reduction in the amount of low density lipoprotein internalised at all concentrations of lipoprotein. 3. 3. There was no effect on the rate of degradation of the low density lipoprotein and no demonstrable changes in the amount of low density lipoprotein bound to the cell surface at high concentrations of low density lipoprotein. 4. 4. Similar results for internalisation and degradation were obtained in a time dependent study. 5. 5. Binding was shown to be reduced in the ethanol treated cells (48 hr) when low concentrations (5 μg/ml) of low density lipoprotein were incubated for short periods (< 3 hr). 6. 6. Scatchard plot analysis indicated that this reduced binding may be due to a reduction of receptor numbers in these cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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