Gompertzian mortality derived from competition between cell-types: Congenital, toxicologic and biometric determinants of longevity

Bass L., Green H.S. and Boxenbaum H. (1989) Gompertzian mortality derived from competition between cell-types: Congenital, toxicologic and biometric determinants of longevity. Journal of Theoretical Biology, 140 2: 263-278. doi:10.1016/S0022-5193(89)80133-X


Author Bass L.
Green H.S.
Boxenbaum H.
Title Gompertzian mortality derived from competition between cell-types: Congenital, toxicologic and biometric determinants of longevity
Journal name Journal of Theoretical Biology   Check publisher's open access policy
ISSN 1095-8541
Publication date 1989-09-22
Sub-type Article (original research)
DOI 10.1016/S0022-5193(89)80133-X
Volume 140
Issue 2
Start page 263
End page 278
Total pages 16
Subject 1100 Agricultural and Biological Sciences
1300 Biochemistry, Genetics and Molecular Biology
2400 Immunology and Microbiology
2604 Applied Mathematics
2611 Modelling and Simulation
2613 Statistics and Probability
2700 Medicine
Abstract Gompertz-Makeham kinetics of population mortality is derived in terms of competition between hypothetical life-prolonging and life-shortening regulatory elements (cells) interacting in each organism by generalized Volterra-type competitive exclusion. The model is developed on two levels, the first applicable to homogeneous populations, and the second, a statistical generalization, applicable to inhomogeneous populations. It offers a natural classification of effects of exogeneous agents on longevity, including hormetic and paradoxical effects of toxic substances, thus relating to problems of risk assessment by extrapolation from high to low doses. Two applications, concerning the effects of radiation on mice and Drosophila imagos, respectively, are used to illustrate the flexibility of the model in the analysis and interpretation of observational data.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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