Physiological pharmacokinetic model for the distribution and elimination of tenoxicam

Kwon K. and Bourne D.W.A. (1987) Physiological pharmacokinetic model for the distribution and elimination of tenoxicam. International Journal of Pharmaceutics, 37 3: 219-226. doi:10.1016/0378-5173(87)90032-9


Author Kwon K.
Bourne D.W.A.
Title Physiological pharmacokinetic model for the distribution and elimination of tenoxicam
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
Publication date 1987
Sub-type Article (original research)
DOI 10.1016/0378-5173(87)90032-9
Volume 37
Issue 3
Start page 219
End page 226
Total pages 8
Subject 3003 Pharmaceutical Science
Abstract A physiologically based pharmacokinetic model for tenoxicam distribution and excretion in the rat was developed. The drug concentrations in plasma and all the tissues except testis were simulated using flow-limited equations, while testis concentrations were calculated using a membrane-limited passive diffusion equation. The elimination of tenoxicam was described in the model by renal and hepatic (metabolic and biliary) excretion with gastro-intestinal secretion and reabsorption. In order to validate the model, 15 tissue samples, plasma (for free and total concentration), urine and feces samples were collected and assayed by HPLC after i.v. injection of tenoxicam (4.5 mg/kg). Good agreements between simulation and experimental data over a 24-h period following drug administration were obtained for plasma and tissues. The terminal half-life of tenoxicam was 8.8 h in plasma and ranged in tissues from 6.1 h in intestine to 10.6 h in brain. The fraction of free tenoxicam in plasma ranged from 1.2 to 2.1% of the total tenoxicam concentration (5.7-21.9 μ/ml).
Keyword Pharmacokinetics
Physiological model
Rat
Tenoxicam
Tissue concentration Summary
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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