Nematospiroides dubius: Direct and correlated responses to selection for high and low immune responsiveness in mice

Sitepu P., Brindley P.J. and Dobson C. (1986) Nematospiroides dubius: Direct and correlated responses to selection for high and low immune responsiveness in mice. Experimental Parasitology, 61 1: 57-64. doi:10.1016/0014-4894(86)90135-9


Author Sitepu P.
Brindley P.J.
Dobson C.
Title Nematospiroides dubius: Direct and correlated responses to selection for high and low immune responsiveness in mice
Journal name Experimental Parasitology   Check publisher's open access policy
ISSN 1090-2449
Publication date 1986
Sub-type Article (original research)
DOI 10.1016/0014-4894(86)90135-9
Volume 61
Issue 1
Start page 57
End page 64
Total pages 8
Subject 2403 Immunology
2405 Parasitology
2725 Infectious Diseases
Abstract High and low immune responder lines of mice were bred selectively from an allogeneic stock over 10 generations, based on their fecal parasite egg count assayed 3 weeks after reinfection with 100 Nematospiroides dubius larvae. By generation 10, (F10), the low immune response mice voided about 10 times as many fecal N. dubius eggs as the high immune response mice. Realized heritability for the selected trait, fecal egg count after secondary infection (= protective immunity), was 0.35 at F7. F7 was considered the selection limit. Selection for change in fecal egg count did not significantly influence the conformational nor reproductive characteristics of these mice. Significant phenotypic and genetic correlations were evident between the selected character and innate immunity to N. dubius, humoral antibody response to N. dubius infection, and establishment, growth, and reproduction of N. dubius in the selected mice.
Keyword Antibody, agglutinating
Genetics
Heritability, resistance
Immunity, infection
Mouse selective breeding
Mus musculus
Nematode, parasitic
Nematospiroides dubius (= Heligmosomoides polygyrus)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 05 Jul 2016, 01:24:06 EST by System User