Losartan for LIFE in hypertension with left ventricular hyperthrophy?

Doggrell, Sheila A. (2003) Losartan for LIFE in hypertension with left ventricular hyperthrophy?. Expert Opinion on Pharmacotherapy, 4 1: 115-118. doi:10.1517/14656566.4.1.115


Author Doggrell, Sheila A.
Title Losartan for LIFE in hypertension with left ventricular hyperthrophy?
Journal name Expert Opinion on Pharmacotherapy   Check publisher's open access policy
ISSN 1465-6566
1744-7666
Publication date 2003-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/14656566.4.1.115
Open Access Status Not yet assessed
Volume 4
Issue 1
Start page 115
End page 118
Total pages 4
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Abstract When ACE inhibitors are used to lower blood pressure to the same degree as β-adrenoceptor antagonists or calcium channel blockers, ACE inhibitors do not seem to have additional benefits to these agents. In the Losartan Intervention for End Point Reduction in Hypertension study (LIFE), losartan was compared to atenolol in hypertensives with the additional risk factor of left ventricular hypertrophy (LVH). For similar effects on blood pressure, losartan had a greater benefit on the primary composite end point (cardiovascular mortality, stroke and myocardial infarction) than atenolol in the hypertensives with LVH, including a prespecified subgroup of patients with additional diabetes mellitus. Losartan also had a greater ability to reverse LVH than atenolol. Thus, losartan should become the standard treatment for hypertension when LVH is present.
Keyword Hypertension
Left-ventricular hyperthrophy
Losartan
Myocardial infarction
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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