Genome-wide association for milk production and female fertility traits in Canadian dairy Holstein cattle

Nayeri, Shadi, Sargolzaei, Mehdi, Abo-Ismail, Mohammed K., May, Natalie, Miller, Stephen P., Schenkel, Flavio, Moore, Stephen S. and Stothard, Paul (2016) Genome-wide association for milk production and female fertility traits in Canadian dairy Holstein cattle. BMC Genetics, 17 1: . doi:10.1186/s12863-016-0386-1

Author Nayeri, Shadi
Sargolzaei, Mehdi
Abo-Ismail, Mohammed K.
May, Natalie
Miller, Stephen P.
Schenkel, Flavio
Moore, Stephen S.
Stothard, Paul
Title Genome-wide association for milk production and female fertility traits in Canadian dairy Holstein cattle
Journal name BMC Genetics   Check publisher's open access policy
ISSN 1471-2156
Publication date 2016-06-10
Year available 2016
Sub-type Article (original research)
DOI 10.1186/s12863-016-0386-1
Open Access Status DOI
Volume 17
Issue 1
Total pages 11
Place of publication London, United Kingdom
Publisher BioMed Central Ltd.
Collection year 2017
Language eng
Formatted abstract
Background: Genome-wide association studies (GWAS) are a powerful tool for detecting genomic regions explaining variation in phenotype. The objectives of the present study were to identify or refine the positions of genomic regions affecting milk production, milk components and fertility traits in Canadian Holstein cattle, and to use these positions to identify genes and pathways that may influence these traits.

Result: Several QTL regions were detected for milk production (MILK), fat production (FAT), protein production (PROT) and fat and protein deviation (FATD, PROTD respectively). The identified QTL regions for production traits (including milk production) support previous findings and some overlap with genes with known relevant biological functions identified in earlier studies such as DGAT1 and CPSF1. A significant region on chromosome 21 overlapping with the gene FAM181A and not previous linked to fertility in dairy cattle was identified for the calving to first service interval and days open. A functional enrichment analysis of the GWAS results yielded GO terms consistent with the specific phenotypes tested, for example GO terms GO:0007595 (lactation) and GO:0043627 (response to estrogen) for milk production (MILK), GO:0051057 (positive regulation of small GTPase mediated signal transduction) for fat production (FAT), GO:0040019 (positive regulation of embryonic development) for first service to calving interval (CTFS) and GO:0043268 (positive regulation of potassium ion transport) for days open (DO). In other cases the connection between the enriched GO terms and the traits were less clear, for example GO:0003279 (cardiac septum development) for FAT and GO:0030903 (notochord development) for DO trait.

Conclusion: The chromosomal regions and enriched pathways identified in this study confirm several previous findings and highlight new regions and pathways that may contribute to variation in production or fertility traits in dairy cattle.
Keyword Female fertility and milk production
Functional analysis
Genome-wide association analysis
Holstein cattle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Alliance for Agriculture and Food Innovation
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