Propranolol in pregnancy three year prospective study

Livingstone I., Craswell P.W., Bevan E.B., Smith M.T. and Eadie M.J. (1983) Propranolol in pregnancy three year prospective study. Hypertension in Pregnancy, B2 2: 341-350. doi:10.3109/10641958309006092


Author Livingstone I.
Craswell P.W.
Bevan E.B.
Smith M.T.
Eadie M.J.
Title Propranolol in pregnancy three year prospective study
Journal name Hypertension in Pregnancy   Check publisher's open access policy
ISSN 1064-1955
Publication date 1983
Sub-type Article (original research)
DOI 10.3109/10641958309006092
Volume B2
Issue 2
Start page 341
End page 350
Total pages 10
Publisher Informa Healthcare
Subject 2729 Obstetrics and Gynaecology
2724 Internal Medicine
Abstract We compared propranolol with methyldopa in a randomized prospective study of 28 women with pregnancy associated hypertension. Both drugs were equally effective in controlling maternal hypertension. There was no significant difference in the birthweights of the babies in each group. However one infant born to a mother receiving propranolot had symptomatic hypoglycaemia. The mean peak levels of propranolol, propranolol glucuronide, 4-hydroxypropranolol, and 4-hydroxypropranolol glucuronide were not significantly different in the first, second, third trimesters and at least 3 months post partum. The mean peak plasma level of naphthoxylactic acid however was significantly less in the third trimester compared with post partum levels. Propranolol and its metabolites were found to cross into breast milk with the maximum dose likely to be ingested by the infant as either propranolol or propranolol glucuronide being 7 ug of propranolol per 100 g of breast milk, being approximately 0.1% of the maternal dose.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Fri, 01 Jul 2016, 15:56:46 EST by Ms Kate Rowe