A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit h (eiF3h), as an enhancer of variegation in the mouse

Daxinger, Lucia, Oey, Harald, Apedaile, Anwyn, Sutton, Joanne, Ashe, Alyson and Whitelaw, Emma (2012) A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit h (eiF3h), as an enhancer of variegation in the mouse. G3: Genes, Genomes, Genetics, 2 11: 1393-1396. doi:10.1534/g3.112.004036


Author Daxinger, Lucia
Oey, Harald
Apedaile, Anwyn
Sutton, Joanne
Ashe, Alyson
Whitelaw, Emma
Title A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit h (eiF3h), as an enhancer of variegation in the mouse
Journal name G3: Genes, Genomes, Genetics   Check publisher's open access policy
ISSN 2160-1836
Publication date 2012-11-01
Year available 2012
Sub-type Article (original research)
DOI 10.1534/g3.112.004036
Open Access Status DOI
Volume 2
Issue 11
Start page 1393
End page 1396
Total pages 4
Place of publication Bethesda, MD, United States
Publisher Genetics Society of America
Language eng
Formatted abstract
We have used a forward genetic screen to identify genes required for transgene silencing in the mouse. Previously these genes were found using candidate-based sequencing, a slow and laborintensive process. Recently, whole-exome deep sequencing has accelerated our ability to find the causative point mutations, resulting in the discovery of novel and sometimes unexpected genes. Here we report the identification of translation initiation factor 3, subunit H (eIF3h) in two modifier of murine metastable epialleles (Mommes) lines. Mice carrying mutations in this gene have not been reported previously, and a possible involvement of eIF3h in transcription or epigenetic regulation has not been considered.
Keyword EIF3h
Epigenetics
Forward genetic screen
Mouse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 29 Jun 2016, 14:18:33 EST by Harald Oey on behalf of Learning and Research Services (UQ Library)