Streptococcus pyogenes adhesion and colonization

Brouwer, Stephan, Barnett, Timothy C., Rivera-Hernandez, Tania, Rohde, Manfred and Walker, Mark J. (2016) Streptococcus pyogenes adhesion and colonization. FEBS Letters, 590 21: 3739-3757. doi:10.1002/1873-3468.12254


Author Brouwer, Stephan
Barnett, Timothy C.
Rivera-Hernandez, Tania
Rohde, Manfred
Walker, Mark J.
Title Streptococcus pyogenes adhesion and colonization
Formatted title
Streptococcus pyogenes adhesion and colonization
Journal name FEBS Letters   Check publisher's open access policy
ISSN 1873-3468
0014-5793
Publication date 2016-07-01
Year available 2016
Sub-type Article (original research)
DOI 10.1002/1873-3468.12254
Open Access Status Not Open Access
Volume 590
Issue 21
Start page 3739
End page 3757
Total pages 19
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2017
Language eng
Formatted abstract
Streptococcus pyogenes (group A Streptococcus, GAS) is a human-adapted pathogen responsible for a wide spectrum of disease. GAS can cause relatively mild illnesses, such as strep throat or impetigo, and less frequent but severe life-threatening diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome. GAS is an important public health problem causing significant morbidity and mortality worldwide. The main route of GAS transmission between humans is through close or direct physical contact, and particularly via respiratory droplets. The upper respiratory tract and skin are major reservoirs for GAS infections. The ability of GAS to establish an infection in the new host at these anatomical sites primarily results from two distinct physiological processes, namely bacterial adhesion and colonization. These fundamental aspects of pathogenesis rely upon a variety of GAS virulence factors, which are usually under strict transcriptional regulation. Considerable progress has been made in better understanding these initial infection steps. This review summarizes our current knowledge of the molecular mechanisms of GAS adhesion and colonization.
Keyword Streptococcus pyogenes
Adherence
Biofilm
Colonization
Pathogenesis
Transcriptional regulation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Tue, 28 Jun 2016, 22:25:32 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences