RISH III. Haplotype-sharing in immune responses

Daunter B. (1985) RISH III. Haplotype-sharing in immune responses. Medical Hypotheses, 17 1: 79-93. doi:10.1016/0306-9877(85)90022-2


Author Daunter B.
Title RISH III. Haplotype-sharing in immune responses
Journal name Medical Hypotheses   Check publisher's open access policy
ISSN 0306-9877
Publication date 1985
Sub-type Article (original research)
DOI 10.1016/0306-9877(85)90022-2
Volume 17
Issue 1
Start page 79
End page 93
Total pages 15
Subject 1309 Developmental Biology
2700 Medicine
3002 Drug Discovery
Abstract A number of hypotheses have been proposed for the reactivity of lymphocytes with allogeneic tissue. However, these hypotheses have not been generally accepted for they cannot accommodate the observation that lymphocytes from chimeras cooperate with each other. Also, only a few percent of lymphocytes react with allogeneic tissue in rejection reactions. RISH considers that in the chimeric situation the thymus may modulate the expression of histocompatibility antigens, allowing only the common antigens to be expressed. This will result in the expression of one complementary haplotype on each T-lymphocyte. Thus immune reactivity will be induced by cells supplying the complementary haplotype. This will allow reactions with target cells and between lymphocytes by haplotype sharing. In those situations in which codominance of histocompatibility antigens has not been demonstrated, RISH considers this to result from structural-acomplementarity. That is, there has been a cross-over between the maternal and paternal chromosomes bearing the histocompatibility genes. This results in reorientation of the histocompatibility antigens at the cell surface with loss of like-cell identification. The small percentage of lymphocytes reacting with allogeneic tissue is considered to represent tissue-specific T-lymphocytes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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