Genetic Control of Liability to Infection with Nematospiroides Dubius in Mice: Direct and Correlated Responses to Selection of Mice for Faecal Parasite Egg Count

Brindley P.J. and Dobson C. (1983) Genetic Control of Liability to Infection with Nematospiroides Dubius in Mice: Direct and Correlated Responses to Selection of Mice for Faecal Parasite Egg Count. Parasitology, 87 1: 113-127. doi:10.1017/S003118200005246X


Author Brindley P.J.
Dobson C.
Title Genetic Control of Liability to Infection with Nematospiroides Dubius in Mice: Direct and Correlated Responses to Selection of Mice for Faecal Parasite Egg Count
Journal name Parasitology   Check publisher's open access policy
ISSN 1469-8161
Publication date 1983
Sub-type Article (original research)
DOI 10.1017/S003118200005246X
Volume 87
Issue 1
Start page 113
End page 127
Total pages 15
Subject 2405 Parasitology
2725 Infectious Diseases
1103 Clinical Sciences
Abstract Mice selected as liable (L) and refractory (R) over 10 generations voided significantly more and less Nematospiroides dubius eggs compared with randomly mated (Rd) mice after primary infection with 100 larvae. Strong positive correlation was found between the numbers of N. dubius eggs in mouse faeces and the numbers of adult N. dubius recovered from mice culled from the R, Rd and L colonies. Selection limit based on a faecal e.p.g. was reached in the L mice after 9 generations whereas the faecal N. dubius e.p.g. voided by the R mice continued to decline throughout selection. In contrast, no change in worm numbers was found in L or R mice after 6 generations. The refractory state of the trait, liability to infection with N. dubius, was inherited as a dominant character with a realized heritability value of ˜ 0.2. Differential correlated responses from N. dubius infectivity compared with N. dubius fecundity and growth indicated murine genetic control of this trait by 2 major genetic units. In general, there were negative phenotypic and genetic correlations between the faecal N. dubius e.p.g. of mice and murine morphological conformation, but positive correlations between the faecal N. dubius e.p.g. of selected mice and establishment, growth and fecundity of N. dubius populations in these mice. There was little correlation between the faecal N. dubius e.p.g. after primary infection and anti-N. dubius antibody titres and parasite female/male sex-ratio.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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