Aspirin Treatment of Migraine Attacks: Plasma Drug Level Data

Ross-Lee L., Heazlewood V., Tyrer J.H. and Eadie M.J. (1982) Aspirin Treatment of Migraine Attacks: Plasma Drug Level Data. Cephalalgia, 2 1: 9-14. doi:10.1046/j.1468-2982.1982.0201009.x


Author Ross-Lee L.
Heazlewood V.
Tyrer J.H.
Eadie M.J.
Title Aspirin Treatment of Migraine Attacks: Plasma Drug Level Data
Journal name Cephalalgia   Check publisher's open access policy
ISSN 1468-2982
Publication date 1982
Sub-type Article (original research)
DOI 10.1046/j.1468-2982.1982.0201009.x
Volume 2
Issue 1
Start page 9
End page 14
Total pages 6
Subject 2728 Clinical Neurology
Abstract Plasma aspirin and salicylate levels were measured at intervals over a two hour period during migraine attacks in 10 subjects given 900 mg oral aspirin alone, in 10 subjects given 900 mg oral aspirin plus 10 mg oral metoclopramide, and in 10 subjects given 900 mg oral aspirin plus an intramuscular injection of 10 mg metoclopramide. Higher peak aspirin and salicylate levels occurred in patients given aspirin with metoclopramide. Aspirin tended to appear in plasma earlier in patients given aspirin with oral metoclopramide than in patients given aspirin alone, or aspirin with intramuscular metoclopramide. Patients given aspirin with oral metoclopramide tended to obtain better early pain relief than the other two treatment groups, though by one hour from dosage use of injected metoclopramide was also associated with better pain relief.
Keyword Absorption
aspirin
metoclopramide
migraine
salicylate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 07:48:55 EST by System User