Experimental infection of mice with Rhodococcus equi: Differences in virulence between strains

Bowles P.M., Woolcock J.B. and Mutimer M.D. (1987) Experimental infection of mice with Rhodococcus equi: Differences in virulence between strains. Veterinary Microbiology, 14 3: 259-268. doi:10.1016/0378-1135(87)90113-1


Author Bowles P.M.
Woolcock J.B.
Mutimer M.D.
Title Experimental infection of mice with Rhodococcus equi: Differences in virulence between strains
Journal name Veterinary Microbiology   Check publisher's open access policy
ISSN 0378-1135
Publication date 1987-01-01
Sub-type Article (original research)
DOI 10.1016/0378-1135(87)90113-1
Volume 14
Issue 3
Start page 259
End page 268
Total pages 10
Subject 1103 Clinical Sciences
2404 Microbiology
3400 Veterinary
Abstract The growth kinetics in outbred mice of clinical and environmental isolates of Rhodococcus equi were followed by serial bacterial enumeration of organ homogenates. Clinical isolates multiplied until Day 4 before being progressively cleared, but could still be recovered from the liver at 3-4 weeks post-infection. Intravenous inoculation of clinical strains was associated with histopathological responses very similar to those elicited by intravenous infection with various facultative intracellular parasites. Whereas lesions in mice and foals at 7-9 days following respiratory infection are those of severe bronchopneumonia with massive consolidation, a week later the patterns of host response have diverged as the murine lesions resolve. The type strain, NCTC 1621 and 4-6 environmental isolates were eliminated without prior multiplication and these strains caused negligible lesions. The two environmental strains which behaved as the clinical strains were recovered from a stud with an R. equi problem. No association of colonial morphology of R. equi with virulence was apparent.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 19 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 28 Jun 2016, 17:03:40 EST by System User