Transferrin receptor distribution and regulation in the rat small intestine. Effect of iron stores and erythropoiesis

Anderson G.J., Powell L.W. and Halliday J.W. (1990) Transferrin receptor distribution and regulation in the rat small intestine. Effect of iron stores and erythropoiesis. Gastroenterology, 98 3: 576-585.

Author Anderson G.J.
Powell L.W.
Halliday J.W.
Title Transferrin receptor distribution and regulation in the rat small intestine. Effect of iron stores and erythropoiesis
Journal name Gastroenterology   Check publisher's open access policy
ISSN 0016-5085
Publication date 1990
Sub-type Article (original research)
Volume 98
Issue 3
Start page 576
End page 585
Total pages 10
Subject 2715 Gastroenterology
Abstract A combination of biochemical quantitation and immunohistochemistry has been used to examine in detail transferrin receptor distribution and expression in the rat small intestine and its relationship to iron absorption. Receptor numbers were quantitated by transferrin binding to preparations of basolateral or brush-border membranes. Receptors were demonstrated on the basolateral membranes of the gut cells, but not on the brush-border fraction. Apotransferrin demonstrated little binding to basolateral membranes at physiological pH. Dietary or parenteral iron loading of animals produced a significant decline in transferrin binding, whereas binding was increased in iron deficiency. These data were confirmed by immunohistochemical studies using a monoclonal antibody to the transferrin receptor. When iron absorption was increased threefold following acute hemolysis and without a decrease in body iron stores, there was no change in transferrin receptor number. These data indicate that intestinal transferrin receptors may be regulated by body iron stores but suggest that they are not directly involved in iron absorption.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 28 Jun 2016, 06:53:13 EST by System User