Optimal feeding policy for recombinant protein production via the yeast saccharomyces cerevisiae in fed-batch culture

Nurmianto L., Greenfield P.F. and Lee P.L. (1994) Optimal feeding policy for recombinant protein production via the yeast saccharomyces cerevisiae in fed-batch culture. Process Biochemistry, 29 1: 55-68. doi:10.1016/0032-9592(94)80059-6


Author Nurmianto L.
Greenfield P.F.
Lee P.L.
Title Optimal feeding policy for recombinant protein production via the yeast saccharomyces cerevisiae in fed-batch culture
Journal name Process Biochemistry   Check publisher's open access policy
ISSN 1359-5113
Publication date 1994
Sub-type Article (original research)
DOI 10.1016/0032-9592(94)80059-6
Volume 29
Issue 1
Start page 55
End page 68
Total pages 14
Subject 1303 Specialist Studies in Education
1605 Policy and Administration
2201 Applied Ethics
2209 Industrial and Manufacturing Engineering
2402 Applied Microbiology and Biotechnology
1502 Banking, Finance and Investment
Abstract Optimisation of the glucose feed rate and feed concentration for the production of a recombinant protein (β-galactosidase) with respect to two different objective functions is addressed in this work. The performance indices optimised were recombinant protein productivity and overall production cost, respectively. The optimisation was based on a model developed and validated independently. The design of a suboptimal feeding policy which is more practical and easier to implement was confirmed experimentally. Sensitivity analyses of the model parameters allowed the effect of disturbances on recombinant protein productivity to be assessed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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