Neuropeptide Y modulation of A1 noradrenergic neuron input to supraoptic vasopressin cells

Khanna S., Sibbald J.R. and Day T.A. (1993) Neuropeptide Y modulation of A1 noradrenergic neuron input to supraoptic vasopressin cells. Neuroscience Letters, 161 1: 60-64. doi:10.1016/0304-3940(93)90140-G


Author Khanna S.
Sibbald J.R.
Day T.A.
Title Neuropeptide Y modulation of A1 noradrenergic neuron input to supraoptic vasopressin cells
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 1993-10-14
Sub-type Article (original research)
DOI 10.1016/0304-3940(93)90140-G
Volume 161
Issue 1
Start page 60
End page 64
Total pages 5
Subject 2800 Neuroscience
Abstract A1 noradrenaline (NA) neurons provide a direct excitatory input to supraoptic nucleus (SON) vasopressin (VP) cells. Many A1 cells contain neuropeptide Y (NPY) and past studies have established that NPY exerts excitatory postsynaptic effects on VP cell activity. We have now investigated whether NPY might also modulate A1 input to VP cells via presynaptic mechanisms. Experiments done in pentobarbitone-anesthetized rats demonstrated that SON application of NPY (10 μM) excited VP cells but also depressed their response to activation of the A1 input. These two effects were not correlated, suggesting independent mechanisms. The putative Y1 agonist [Leu31,Pro34]NPY (10 μM) also excited VP cells but did not alter their response to activation of the A1 input. In contrast, the putative Y2 receptor agonist Ac-[Leu28,Leu31]NPY24-36 mimicked the synaptic depression produced by NPY but did not significantly alter spontaneous activity. These data are consistent with the proposal that NPY acts on Y1-like receptors to excite VP cells but can also act on a presynaptic Y2-like receptor to depress A1-VP cell synaptic transmission.
Keyword A1 noradrenergic cell group
Neuropeptide Y
Neurosecretory cell
Presynaptic receptor
Supraoptic nucleus
Vasopressin cell
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 20 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 28 Jun 2016, 06:30:03 EST by System User