Pressure-induced dissociation of aggregates of myelin proteolipid protein

Gow A., Winzor D.J. and Smith R. (1985) Pressure-induced dissociation of aggregates of myelin proteolipid protein. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 828 3: 383-386. doi:10.1016/0167-4838(85)90321-8


Author Gow A.
Winzor D.J.
Smith R.
Title Pressure-induced dissociation of aggregates of myelin proteolipid protein
Journal name Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular
ISSN 0167-4838
Publication date 1985-04-29
Sub-type Article (original research)
DOI 10.1016/0167-4838(85)90321-8
Volume 828
Issue 3
Start page 383
End page 386
Total pages 4
Subject 1303 Specialist Studies in Education
1304 Biophysics
1312 Molecular Biology
1315 Structural Biology
Abstract Sedimentation velocity and equilibrium experiments have revealed an extremely pressure-sensitive aggregation of myelin proteolipid protein in the presence of Triton X-100, dissociation of the protein aggregate being observed at pressures that are several orders of magnitude lower than those effecting disaggregation of many other proteins. These results highlight the need to employ a range of angular velocities in sedimentation studies of intrinsic membrane protein.
Keyword Membrane protein
Molecular weight determination
Myelin proteolipid protein
Pressure effect
Protein aggregation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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