A scanning and transmission electron microscopical study of the morphogenesis of human colonic villi

Bell L. and Williams L. (1982) A scanning and transmission electron microscopical study of the morphogenesis of human colonic villi. Anatomy and Embryology, 165 3: 437-455. doi:10.1007/BF00305579


Author Bell L.
Williams L.
Title A scanning and transmission electron microscopical study of the morphogenesis of human colonic villi
Journal name Anatomy and Embryology   Check publisher's open access policy
ISSN 0340-2061
Publication date 1982
Sub-type Article (original research)
DOI 10.1007/BF00305579
Volume 165
Issue 3
Start page 437
End page 455
Total pages 19
Publisher Springer-Verlag
Subject 2710 Embryology
2702 Anatomy
1309 Developmental Biology
1307 Cell Biology
Abstract The morphogenetic events that occur in the development of villi in human foetal colon have been observed by light microscopy and scanning and transmission electron microscopy. At nine weeks, the colon is a simple tube composed of pseudostratified columnar epithelium and mesenchyme. By ten weeks, up to eight longitudinal ridges have formed by an elongation of individual epithelial cells. Even as the ridges are forming, the bases of some of the ridges become indented with mesenchyme thus forming longitudinal mucosal folds. By eleven and a half weeks, these have folded in a concertina fashion forming a longitudinal zig-zag pattern. From ten and a half weeks, small lumina develop within the epithelium near to its base. At this stage, they are not in continuity with the main lumen. Extension of these lumina to the main luminal surface and exfoliation of redundant cells result in division of the zig-zag folds into broad primary villi. Division of the primary villi occurs when cyst-like structures which develop within the pseudostratified columnar epithelium of the primary villi enlarge and extend to the lumen. Together with upgrowth of mesenchyme this results in small secondary villi with simple columnar epithelium.
Keyword Colon
Fetal
Microscopy, electron, scanning
Morphogenesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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