Potential role of anti-oncogenes in ageing

Ferluga J. (1990) Potential role of anti-oncogenes in ageing. Mechanisms of Ageing and Development, 53 3: 267-275. doi:10.1016/0047-6374(90)90044-G

Author Ferluga J.
Title Potential role of anti-oncogenes in ageing
Journal name Mechanisms of Ageing and Development   Check publisher's open access policy
ISSN 0047-6374
Publication date 1990-04-30
Sub-type Article (original research)
DOI 10.1016/0047-6374(90)90044-G
Volume 53
Issue 3
Start page 267
End page 275
Total pages 9
Subject 1302 Curriculum and Pedagogy
1303 Specialist Studies in Education
1309 Developmental Biology
2806 Developmental Neuroscience
Abstract Some observations on cellular senescence are discussed regarding the possibility that the postulated genes, which bring about the DNA synthesis block of senescent fibroblasts, might be similar to those designated as anti-oncogenes or tumour suppressor genes. The latter genes have been defined by tumorogenicity tests of hybrids from fused tumour and normal cells, of which the retinoblastoma (RB) gene is a prototype. Similarities between the two systems are considered, which are consistent with the assumption that senescent growth arrest, like the suppression of tumorogenicity of the hybrids, might be effected by anti-oncogenes via inhibition of cellular oncogenes in their growth signal transduction functions. A link may be provided by the finding of a direct interaction of certain DNA tumour virus oncoproteins with the RB gene product p105-RB, together with observations that the tumour viruses are also able to reinitiate DNA synthesis in growth arrested senescent fibroblasts. The possibility is also discussed that some silent retinoblastoma-like genes might become aberrantly expressed in senescent cells owing to a progressive loss of 5-methyl cytosine residues of DNA.
Keyword Cellular senescence
DNA viruses
Terminal differentiation
Tumor supressor genes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Citation counts: Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Tue, 28 Jun 2016, 05:39:40 EST by System User