Canine biphasic synovial sarcoma: case report and immunohistochemical characterization

Loukopoulos, Panayiotis, Heng, Hock Gan and Arshad, Habibah (2004) Canine biphasic synovial sarcoma: case report and immunohistochemical characterization. Journal of Veterinary Science, 5 2: 173-180.

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Author Loukopoulos, Panayiotis
Heng, Hock Gan
Arshad, Habibah
Title Canine biphasic synovial sarcoma: case report and immunohistochemical characterization
Journal name Journal of Veterinary Science   Check publisher's open access policy
ISSN 1229-845X
Publication date 2004
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 5
Issue 2
Start page 173
End page 180
Total pages 8
Place of publication Seoul, Republic of Korea
Publisher Korean Society of Veterinary Science / Daehan Suui Hakoe
Subject 3400 Veterinary
Abstract The clinical, radiological and pathologic features of a biphasic synovial sarcoma in the left elbow joint of a two-year-old male Rottweiler are presented. The tumor showed positive immunoreactivity for vimentin, Epithelial Membrane Antigen (EMA), p53 and PCNA, while it was negative for the cytokeratin used, S-100, Rb and p21. Immunohistochemistry for EMA allowed the identification of epithelioid components of synovial sarcoma, and may, therefore, contribute in establishing a diagnosis of biphasic synovial sarcoma. Intratumoral variation in PCNA immunoreactivity was minimal, indicating that the various tumor components proliferate at more or less similar rates. Overall, the characterized immunohistochemical profile for canine synovial sarcoma, not defined previously, may provide clues to the histogenesis of the phenotypically mesenchymal and epithelial elements of the tumor, and may be of value in the differential diagnosis of challenging cases, decreasing the risk of under- and mis-diagnosis. Although more cases need to be studied to determine whether there is a consistent pattern of immunostaining in canine synovial sarcoma, its potential significance is discussed in relation to the histogenesis, molecular pathology and differential diagnosis of canine synovial sarcoma.
Keyword Sarcoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
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