Plasma Level Monitoring of Anticonvulsants

Eadie M.J. (1976) Plasma Level Monitoring of Anticonvulsants. Clinical Pharmacokinetics, 1 1: 52-66. doi:10.2165/00003088-197601010-00005

Author Eadie M.J.
Title Plasma Level Monitoring of Anticonvulsants
Journal name Clinical Pharmacokinetics   Check publisher's open access policy
ISSN 1179-1926
Publication date 1976
Sub-type Article (original research)
DOI 10.2165/00003088-197601010-00005
Volume 1
Issue 1
Start page 52
End page 66
Total pages 15
Subject 2736 Pharmacology (medical)
3004 Pharmacology
3000 Pharmacology, Toxicology and Pharmaceutics
Abstract The plasma concentrations of anticonvulsant drugs, and of certain of their biologically active metabolites, tend to be proportionate to the antiepileptic effects of these drugs. Consequently, anticonvulsant drug levels in plasma are monitored to help guide the clinician in managing his patients’ epilepsies. In making use of the measurements, the clinician needs to know the relation between plasma level and biological effect for the various drugs. He also needs to have some awareness of simple pharmacokinetic principles. These are important in deciding when plasma levels should be monitored in relation to the patients’ clinical state, to the dosage interval, and to change in the dosage of anticonvulsant or other drug. The clinician also requires pharmacokinetic knowledge in altering anticonvulsant drug dosage in his patients, and in interpreting plasma anticonvulsant level data, particularly when the patient is concurrently suffering from non-neurological disease. The ability to monitor plasma anticonvulsant levels has appreciably improved the treatment of epilepsy, but to obtain maximum benefits from the method, both pharmacokinetic insight and clinical wisdom are required.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Citation counts: Scopus Citation Count Cited 54 times in Scopus Article | Citations
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Created: Tue, 28 Jun 2016, 04:16:15 EST by System User