A review of new developments in type 2 diabetes in human beings and cats

Lutz T.A. and Rand J.S. (1993) A review of new developments in type 2 diabetes in human beings and cats. British Veterinary Journal, 149 6: 527-536. doi:10.1016/S0007-1935(05)80037-5


Author Lutz T.A.
Rand J.S.
Title A review of new developments in type 2 diabetes in human beings and cats
Journal name British Veterinary Journal   Check publisher's open access policy
ISSN 0007-1935
Publication date 1993-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0007-1935(05)80037-5
Volume 149
Issue 6
Start page 527
End page 536
Total pages 10
Subject 3400 Veterinary
Abstract Cats appear to be one of the few non-human species that develop a type of diabetes mellitus analogous to human Type 2, or non-insulin-dependent diabetes mellitus (NIDDM). In this review, some current theories on diabetogenesis are discussed. In both cats and human beings, Type 2 diabetes is characterized by impaired insulin secretion due to a functional defect in pancreatic -cells, and insulin resistance. In both species, amyloid deposition occurs in pancreatic islets and is derived from the newly discovered pancreatic hormone islet amyloid polypeptide (IAPP), or amylin. Amylin also reduces insulin secretion and induces insulin resistance. Thus, the hypothesis of amylin being intimately involved in the pathogenesis of human and feline Type 2 diabetes appears justified. Obesity is a frequent concomitant problem in feline and human Type 2 diabetes and contributes to the insulin resistance characteristic of the disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import
 
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