Quantitative oxidative enzyme histochemistry of the spinal cord. Part 2. Relation of cell size and enzyme activity to vulnerability to ischaemia

Penny J.E., Kukums J.R., Tyrer J.H. and Eadie M.J. (1975) Quantitative oxidative enzyme histochemistry of the spinal cord. Part 2. Relation of cell size and enzyme activity to vulnerability to ischaemia. Journal of the Neurological Sciences, 26 2: 187-192. doi:10.1016/0022-510X(75)90031-3


Author Penny J.E.
Kukums J.R.
Tyrer J.H.
Eadie M.J.
Title Quantitative oxidative enzyme histochemistry of the spinal cord. Part 2. Relation of cell size and enzyme activity to vulnerability to ischaemia
Journal name Journal of the Neurological Sciences   Check publisher's open access policy
ISSN 0022-510X
Publication date 1975
Sub-type Article (original research)
DOI 10.1016/0022-510X(75)90031-3
Volume 26
Issue 2
Start page 187
End page 192
Total pages 6
Subject 1302 Curriculum and Pedagogy
2728 Clinical Neurology
2746 Surgery
2800 Neuroscience
2806 Developmental Neuroscience
2808 Neurology
Abstract Cytophotometric measurements of the activities of 5 enzymes (succinate, malate, and NAD+-linked isocitrate dehydrogenases from the tricarboxylic cycle, lactate dehydrogenase from the Embden-Meyerhof pathway, and NADH dehydrogenase) were correlated with cell volume for neurones in the anterior horn of rabbit lumbar and cervical spinal cord. The data for succinate and isocitrate dehydrogenases indicated that these enzymes were at higher concentrations in the smaller neurones, which consist largely of interneurones. No preferential localization to particular sizes of cell could be assigned to the other enzymes studied. The relationship between enzyme distribution patterns and their possible role in contributing toward susceptibility to ischaemia of particular sizes of neurones is discussed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 03:23:07 EST by System User