Ethanol increases synaptosomal free calcium concentration

Davidson M., Wilce P. and Shanley B. (1988) Ethanol increases synaptosomal free calcium concentration. Neuroscience Letters, 89 2: 165-169. doi:10.1016/0304-3940(88)90375-8


Author Davidson M.
Wilce P.
Shanley B.
Title Ethanol increases synaptosomal free calcium concentration
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 1988-06-29
Sub-type Article (original research)
DOI 10.1016/0304-3940(88)90375-8
Volume 89
Issue 2
Start page 165
End page 169
Total pages 5
Subject 2800 Neuroscience
Abstract The effect of ethanol on synaptosomal free calcium concentration ([Ca2+]i) and 45Ca2+ uptake was studied in vitro. Synaptosomes were prepared from forebrains of adult rats and incubated in the presence of ethanol 50 500 mM. [Ca2+]i determined by means of the Ca2+-sensitive dye, fura-2, was increased by ethanol in polarized and depolarized synaptosomes, whereas 45Ca2+ uptake was decreased. The results suggest that ethanol may influence neuronal calcium homeostasis by increasing rather than decreasing [Ca2+]i.
Keyword 45Ca2+ uptake
Ethanol
Free calcium
Fura-2
Synaptosome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 01:20:20 EST by System User