Ferritin synthesis in peripheral blood monocytes in idiopathic hemochromatosis

Bassett M.L., Halliday J.W. and Powell L.W. (1982) Ferritin synthesis in peripheral blood monocytes in idiopathic hemochromatosis. The Journal of Laboratory and Clinical Medicine, 100 1: 137-145.

Author Bassett M.L.
Halliday J.W.
Powell L.W.
Title Ferritin synthesis in peripheral blood monocytes in idiopathic hemochromatosis
Journal name The Journal of Laboratory and Clinical Medicine   Check publisher's open access policy
ISSN 0022-2143
Publication date 1982
Sub-type Article (original research)
Volume 100
Issue 1
Start page 137
End page 145
Total pages 9
Subject 2700 Medicine
2734 Pathology and Forensic Medicine
Abstract RE ferritin synthesis in IHC was studied in MØs isolated from peripheral blood. Twelve phlebotomized hemochromatosis patients with normal body iron stores and 12 healthy control subjects were studied. MØs in culture were exposed to iron as either ferric ammonium citrate or iron dextran, and ferritin synthesis was determined by measurement of 3H-leucine incorporation after isolation of ferritin by a quantitative immunoadsorbent technique. Iron at concentrations of 150 and 300 μM induced de novo ferritin synthesis, increasing both 3H-leucine incorporation into ferritin and cellular ferritin content. However, no differences were observed between hemochromatosis and control MØs with respect to basal or iron-stimulated ferritin synthesis. This study has demonstrated that MØ ferritin synthesis in IHC does not differ from MØ ferritin synthesis in normal subjects and therefore suggests that the reported abnormalities in RE iron storage in IHC are not related to an inability of RE cells to synthesize ferritin.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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