Effect of phenelzine on the metabolism and membranal transport of glucose in brain

Ridge J.W. and Stanley H.M. (1971) Effect of phenelzine on the metabolism and membranal transport of glucose in brain. Biochemical Pharmacology, 20 8: 1811-1819. doi:10.1016/0006-2952(71)90379-0


Author Ridge J.W.
Stanley H.M.
Title Effect of phenelzine on the metabolism and membranal transport of glucose in brain
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 1971
Sub-type Article (original research)
DOI 10.1016/0006-2952(71)90379-0
Volume 20
Issue 8
Start page 1811
End page 1819
Total pages 9
Subject 3004 Pharmacology
Abstract A colorimetric method for the estimation of phenelzine (β-phenylethylhydrazine) based on its reaction with p-dimethylaminobenzaldehyde is presented. Using this method it was shown that in vivo phenelzine rapidly penetrated all regions of the brain. In vitro with glucose as substrate the drug inhibited the respiration of tissue slices from all regions of the brain; with pyruvate as substrate the inhibition was much weaker and slower to develop. It was concluded that the inhibition of respiration was due to the drug's reducing the permeability of the cell membrane to glucose, since the respiration of brain homogenates was not inhibited and that of slices was more resistant to the action of the drug when the glucose concentration in the medium was increased. It was also shown that phenelzine did not inhibit any of the enzymes of glycolysis nor did it react to any significant extent with any of the glycolytic intermediates.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 00:46:25 EST by System User