Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial

de Courten, Barbora, de Courten, Maximilian P. J., Soldatos, Georgia, Dougherty, Sonia L., Straznicky, Nora, Schlaich, Markus, Sourris, Karly C., Chand, Vibhasha, Scheijen, Jean L. J. M., Kingwell, Bronwyn A., Cooper, Mark E., Schalkwijk, Casper G., Walker, Karen Z. and Forbes, Josephine M. (2016) Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial. American Journal of Clinical Nutrition, 103 6: 1426-1433. doi:10.3945/ajcn.115.125427


Author de Courten, Barbora
de Courten, Maximilian P. J.
Soldatos, Georgia
Dougherty, Sonia L.
Straznicky, Nora
Schlaich, Markus
Sourris, Karly C.
Chand, Vibhasha
Scheijen, Jean L. J. M.
Kingwell, Bronwyn A.
Cooper, Mark E.
Schalkwijk, Casper G.
Walker, Karen Z.
Forbes, Josephine M.
Title Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 1938-3207
0002-9165
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.3945/ajcn.115.125427
Open Access Status Not Open Access
Volume 103
Issue 6
Start page 1426
End page 1433
Total pages 8
Place of publication Bethesda, MD United States
Publisher American Society for Nutrition
Collection year 2017
Language eng
Formatted abstract
Background: The consumption of advanced glycation end products (AGEs) has increased because of modern food processing and has been linked to the development of type 2 diabetes in rodents.

Objective: We determined whether changing dietary AGE intake could modulate insulin sensitivity and secretion in healthy, overweight individuals.

Design: We performed a double-blind, randomized, crossover trial of diets in 20 participants [6 women and 14 men; mean ± SD body mass index (in kg/m2): 29.8 ± 3.7]. Isoenergetic- and macronutrient-matched diets that were high or low in AGE content were alternately consumed for 2 wk and separated by a 4-wk washout period. At the beginning and end of each dietary period, a hyperinsulinemic-euglycemic clamp and an intravenous glucose tolerance test were performed. Dietary, plasma and urinary AGEs N-(carboxymethyl)lysine (CML), N-(carboxyethyl)lysin (CEL), and methylglyoxal-derived hydroimadazolidine (MG-H1) were measured with the use of mass spectrometry.

Results: Participants consumed less CML, CEL, and MG-H1 during the low-AGE dietary period than during the high-AGE period (all P < 0.05), which was confirmed by changes in urinary AGE excretion. There was an overall difference in insulin sensitivity of −2.1 mg · kg−1 · min−1 between diets (P = 0.001). Insulin sensitivity increased by 1.3 mg · kg−1 · min−1 after the low-AGE diet (P = 0.004), whereas it showed a tendency to decrease by 0.8 mg · kg−1 · min−1 after the high-AGE diet (P = 0.086). There was no difference in body weight or insulin secretion between diets (P = NS).

Conclusions: A diet that is low in AGEs may reduce the risk of type 2 diabetes by increasing insulin sensitivity. Hence, a restriction in dietary AGE content may be an effective strategy to decrease diabetes and cardiovascular disease risks in overweight individuals. This trial was registered at clinicaltrials.gov as NCT00422253.
Keyword Glycotoxin
Insulin resistance
Insulin secretion
Obesity
Receptors for AGEs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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