Pulmonary zygomycosis in solid organ transplant recipients in the current era

Sun, H. -Y., Aguado, J. M., Bonatti, H., Forrest, G., Gupta, K. L., Safdar, N., John, G. T., Pursell, K. J., Munoz, P., Patel, R., Fortun, J., Martin-Davila, P., Philippe, B., Philit, F., Tabah, A., Terzi, N., Chatelet, V., Kusne, S., Clark, N., Blumberg, E., Julia, M. B., Humar, A., Houston, S., Lass-Florl, C., Johnson, L., Dubberke, E. R., Barron, M. A., Lortholary, O. and Singh, N. (2009) Pulmonary zygomycosis in solid organ transplant recipients in the current era. American Journal of Transplantation, 9 9: 2166-2171. doi:10.1111/j.1600-6143.2009.02754.x


Author Sun, H. -Y.
Aguado, J. M.
Bonatti, H.
Forrest, G.
Gupta, K. L.
Safdar, N.
John, G. T.
Pursell, K. J.
Munoz, P.
Patel, R.
Fortun, J.
Martin-Davila, P.
Philippe, B.
Philit, F.
Tabah, A.
Terzi, N.
Chatelet, V.
Kusne, S.
Clark, N.
Blumberg, E.
Julia, M. B.
Humar, A.
Houston, S.
Lass-Florl, C.
Johnson, L.
Dubberke, E. R.
Barron, M. A.
Lortholary, O.
Singh, N.
Title Pulmonary zygomycosis in solid organ transplant recipients in the current era
Journal name American Journal of Transplantation   Check publisher's open access policy
ISSN 1600-6135
1600-6143
Publication date 2009-09
Sub-type Article (original research)
DOI 10.1111/j.1600-6143.2009.02754.x
Open Access Status Not yet assessed
Volume 9
Issue 9
Start page 2166
End page 2171
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Fifty-eight solid organ transplant recipients with zygomycosis were studied to assess the presentation, radiographic characteristics, risks for extra-pulmonary dissemination and mortality of pulmonary zygomycosis. Pulmonary zygomycosis was documented in 31 patients (53%) and developed a median of 5.5 months (interquartile range, 2-11 months) posttransplantation. In all, 74.2% (23/31) of the patients had zygomycosis limited to the lungs and 25.8% (8/31) had lung disease as part of disseminated zygomycosis; cutaneous/soft tissue (50%, 4/8) was the most common site of dissemination. Pulmonary disease presented most frequently as consolidation/mass lesions (29.0%), nodules (25.8%) and cavities (22.6%). Patients with disseminated disease were more likely to have Mycocladus corymbifer as the causative pathogen. The mortality rate at 90 days after the treatment was 45.2%. In summary, pulmonary zygomycosis is the most common manifestation in solid organ transplant recipients with zygomycosis, and disseminated disease often involves the cutaneous/soft tissue sites but not the brain.
Keyword Pulmonary infection
Transplant
Zygomycosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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