Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update

Yu, Bin, Xing, Hui, Yu, De-Quan and Liu, Hong-Min (2016) Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update. Beilstein Journal of Organic Chemistry, 12 1000-1039. doi:10.3762/bjoc.12.98


Author Yu, Bin
Xing, Hui
Yu, De-Quan
Liu, Hong-Min
Title Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update
Journal name Beilstein Journal of Organic Chemistry   Check publisher's open access policy
ISSN 1860-5397
Publication date 2016-05
Year available 2016
Sub-type Article (original research)
DOI 10.3762/bjoc.12.98
Open Access Status DOI
Volume 12
Start page 1000
End page 1039
Total pages 40
Place of publication Frankfurt am Main, Germany
Publisher Beilstein - Institut zur Foerderung der Chemischen Wissenschaften
Collection year 2017
Language eng
Abstract Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these compounds, enantioenriched 3-hydroxyoxindole scaffolds also exist in natural products and have proven to possess promising biological activities. A large number of catalytic asymmetric strategies toward the construction of 3-hydroxyoxindoles based on transition metal catalysis and organocatalysis have been reported in the last decades. Additionally, 3-hydroxyoxindoles as versatile precursors have also been used in the total synthesis of natural products and for constructing structurally novel scaffolds. In this review, we aim to provide an overview about the catalytic asymmetric synthesis of biologically important 3-substituted 3-hydroxyoxindoles and 3-hydroxyoxindole-based further transformations.
Keyword 3-hydroxyoxindoles
Oxindoles
Organocatalysis
Spirooxindoles
Transition metal catalysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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