Increased brain perfusion contrast with T2-prepared intravoxel incoherent motion (T2prep IVIM) MRI

Federau, Christian and O'Brien, Kieran (2015) Increased brain perfusion contrast with T2-prepared intravoxel incoherent motion (T2prep IVIM) MRI. NMR in Biomedicine, 28 1: 9-16. doi:10.1002/nbm.3223


Author Federau, Christian
O'Brien, Kieran
Title Increased brain perfusion contrast with T2-prepared intravoxel incoherent motion (T2prep IVIM) MRI
Formatted title
Increased brain perfusion contrast with T2-prepared intravoxel incoherent motion (T2prep IVIM) MRI
Journal name NMR in Biomedicine   Check publisher's open access policy
ISSN 1099-1492
Publication date 2015-01
Sub-type Article (original research)
DOI 10.1002/nbm.3223
Volume 28
Issue 1
Start page 9
End page 16
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Formatted abstract
The feasibility to measure brain perfusion using intravoxel incoherent motion (IVIM) MRI has been reported recently with currently clinically available technology. The method is intrinsically local and quantitative, but is contaminated by partial volume effects with cerebrospinal fluid (CSF). Signal from CSF can be suppressed by a 180° inversion recovery (180°-IR) magnetization preparation, but this also leads to strong suppression of blood and brain tissue signal. Here, we take advantage of the different T2 relaxations of blood and brain relative to CSF, and implement a T2-prepared IVIM (T2prep IVIM) inversion recovery acquisition, which permits a recovery of between 43% and 57% of arterial and venous blood magnetization at excitation time compared with the theoretical recovery of between 27% and 30% with a standard 180°-IR. We acquired standard IVIM (IVIM), T2prep IVIM and dynamic susceptibility contrast (DSC) images at 3 T using a 32-multichannel receiver head coil in eight patients with known large high-grade brain tumors. We compared the contrast and contrast-to-noise ratio obtained in the corresponding cerebral blood volume images quantitatively, as well as subjectively by two neuroradiologists. Our findings suggest that quantitative cerebral blood volume contrast and contrast-to-noise ratio, as well as subjective lesion detection, contrast quality and diagnostic confidence, are increased with T2prep IVIM relative to IVIM and DSC.
Keyword Brain
Cerebral blood volume (CBV)
Diffusion
Intravoxel incoherent motion (IVIM)
Perfusion
Tumor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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