Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome

Evans, Andrew H., Katzenschlager, Regina, Paviour, Dominic, O'Sullivan, John D., Appel, Silke, Lawrence, Andrew D. and Lees, Andrew J. (2004) Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome. Movement Disorders, 19 4: 397-405. doi:10.1002/mds.20045

Author Evans, Andrew H.
Katzenschlager, Regina
Paviour, Dominic
O'Sullivan, John D.
Appel, Silke
Lawrence, Andrew D.
Lees, Andrew J.
Title Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
Publication date 2004-04
Sub-type Article (original research)
DOI 10.1002/mds.20045
Open Access Status Not yet assessed
Volume 19
Issue 4
Start page 397
End page 405
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Punding is a term that was coined originally to describe complex prolonged, purposeless, and stereotyped behaviour in chronic amphetamine users. A structured interview of 50 patients with higher dopamine replacement therapy requirements (>800 levodopa equivalent units/day) from 123 unselected patients with Parkinson's disease (PD) from a PD clinic identified 17 (14%) patients with punding. Punding was acknowledged as disruptive and unproductive by the patients themselves, but forcible attempts by family to interrupt the behaviour led to irritability and dysphoria. Punding was associated with very high doses of dopamine replacement therapy often related to a pattern of chronic inappropriate overuse of dopaminergic medication. We believe that this is an underreported, socially disabling phenomenon that is commonly associated with the syndrome of dopamine dysregulation and is phenomenologically distinct from both obsessive-compulsive disorder and mania.
Keyword Dopamine dysregulation syndrome
Parkinson's disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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