Genotypic and phenotypic markers of livestock-associated methicillin-resistant Staphylococcus aureus CC9 in humans

Ye, Xiaohua, Wang, Xiaolin, Fan, Yanping, Peng, Yang, Li, Ling, Li, Shunming, Huang, Jingya, Yao, Zhenjiang and Chen, Sidong (2016) Genotypic and phenotypic markers of livestock-associated methicillin-resistant Staphylococcus aureus CC9 in humans. Applied and Environmental Microbiology, 82 13: 3892-3899. doi:10.1128/AEM.00091-16

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Author Ye, Xiaohua
Wang, Xiaolin
Fan, Yanping
Peng, Yang
Li, Ling
Li, Shunming
Huang, Jingya
Yao, Zhenjiang
Chen, Sidong
Title Genotypic and phenotypic markers of livestock-associated methicillin-resistant Staphylococcus aureus CC9 in humans
Formatted title
Genotypic and phenotypic markers of livestock-associated methicillin-resistant Staphylococcus aureus CC9 in humans
Journal name Applied and Environmental Microbiology   Check publisher's open access policy
ISSN 0099-2240
1098-5336
Publication date 2016-07
Sub-type Article (original research)
DOI 10.1128/AEM.00091-16
Open Access Status File (Publisher version)
Volume 82
Issue 13
Start page 3892
End page 3899
Total pages 8
Place of publication Washington DC, United States
Publisher American Society for Microbiology
Collection year 2017
Language eng
Formatted abstract
Use of antimicrobials in industrial food animal production is associated with the presence of multidrug-resistant Staphylococcus aureus among animals and humans. The livestock-associated (LA) methicillin-resistant S. aureus (MRSA) clonal complex 9 (CC9) is associated with animals and related workers in Asia. This study aimed to explore the genotypic and phenotypic markers of LA-MRSA CC9 in humans. We conducted a cross-sectional study of livestock workers and controls in Guangdong, China. The study participants responded to a questionnaire and provided a nasal swab for S. aureus analysis. The resulting isolates were assessed for antibiotic susceptibility, multilocus sequence type, and immune evasion cluster (IEC) genes. Livestock workers had significantly higher rates of S. aureus CC9 (odds ratio [OR] = 30.98; 95% confidence interval [CI], 4.06 to 236.39) and tetracycline-resistant S. aureus (OR = 3.26; 95% CI, 2.12 to 5.00) carriage than controls. All 19 S. aureus CC9 isolates from livestock workers were MRSA isolates and also exhibited the characteristics of resistance to several classes of antibiotics and absence of the IEC genes. Notably, the interaction analyses indicated phenotype-phenotype (OR = 525.7; 95% CI, 60.0 to 4,602.1) and gene-environment (OR = 232.3; 95% CI, 28.7 to 1,876.7) interactions associated with increased risk for livestock-associated S. aureus CC9 carriage. These findings suggest that livestock-associated S. aureus and MRSA (CC9, IEC negative, and tetracycline resistant) in humans are associated with occupational livestock contact, raising questions about the potential for occupational exposure to opportunistic S. aureus.
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Sub-type: Article (original research)
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Created: Fri, 17 Jun 2016, 09:47:14 EST by Yang Peng on behalf of School of Medicine