Cellular immunity to encephalitogenic peptide in tumour-bearing mice

Yong W.K. and Halliday W.J. (1982) Cellular immunity to encephalitogenic peptide in tumour-bearing mice. British Journal of Cancer, 45 5: 754-761. doi:10.1038/bjc.1982.117

Author Yong W.K.
Halliday W.J.
Title Cellular immunity to encephalitogenic peptide in tumour-bearing mice
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 1532-1827
Publication date 1982
Sub-type Article (original research)
DOI 10.1038/bjc.1982.117
Volume 45
Issue 5
Start page 754
End page 761
Total pages 8
Subject 1306 Cancer Research
2730 Oncology
Abstract Mice bearing a methylcholanthrene-induced tumour were tested for their cell mediated reactivity to the experimental allergic encephalomyelitis (EAE) peptide of human myelin basic protein (MBP) in the leucocyte adherence inhibition (LAI) test. Tested over a range of peptide concentrations, peritoneal cells (PC) from tumour-bearing mice exhibited optimal adherence inhibition at 640 ng/ml; PC from normal and parasite-infected mice were unreactive. The EAE peptide also stimulated PC from tumour-bearing mice in the E-rosette augmentation (ERA) test and in the macrophage migration inhibition (MMI) test. MMI appeared to be the most sensitive assay, in that significant reaction at peptide concentrations well below those giving significant LAI and ERA. LAI reactivity to the peptide was detected 5 days after tumour transplantation, and continued to be detectable even with very large tumours. in vitro assays were confirmed by demonstration of EAE peptide recognition in vivo, in tumour-bearing and tumour-excised mice, using the delayed-type hypersensitivity reaction. The present experiments demonstrate an antigenic determinant in murine tumours, similar to the well-characterized EAE peptide of human MBP, and establish an animal model for study and characterization of common tumour-associated antigens.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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