Tumour-associated antigens in bovine ocular squamous cell carcinoma: Studies with sera from tumour-bearing animals

Kuchroo V.K. and Spradbrow P.B. (1985) Tumour-associated antigens in bovine ocular squamous cell carcinoma: Studies with sera from tumour-bearing animals. Veterinary Immunology and Immunopathology, 9 1: 23-36. doi:10.1016/0165-2427(85)90127-8


Author Kuchroo V.K.
Spradbrow P.B.
Title Tumour-associated antigens in bovine ocular squamous cell carcinoma: Studies with sera from tumour-bearing animals
Journal name Veterinary Immunology and Immunopathology   Check publisher's open access policy
ISSN 0165-2427
Publication date 1985
Sub-type Article (original research)
DOI 10.1016/0165-2427(85)90127-8
Volume 9
Issue 1
Start page 23
End page 36
Total pages 14
Subject 1103 Clinical Sciences
2403 Immunology
3400 Veterinary
Abstract Sera from 21 cattle (10 bovine ocular squamous cell carcinoma (BOSCC) bearing and 11 controls) were tested for antibody reactivity against various cultured cells (BOSCC, normal skin and tumours other than BOSCC), by an indirect immunofluorescence technique. Most of the BOSCC sera reacted with autologous and allogeneic BOSCC cells and did not show any significant reactivity with normal skin cells (autologous or allogeneic). These sera when further tested on 7 different allogeneic or xenogeneic tumour cell types (other than BOSCC), showed significant reactivity only with cultured equine sarcoid and cutaneous papilloma cells. Three of the BOSCC sera did not react with autologous BOSCC cells but reacted indiscriminately with all other allogeneic BOSCC, normal cells and other tumour cells. Most of the control sera did not show any significant reactivity against BOSCC cells except sera from one cow bearing ocular papilloma and 2 healthy normals that were in contact with BOSCC bearing animals. This study suggests that BOSCC cells possess tumour associated antigens that are common to most (if not all) BOSCC cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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