Some effects on muscle and nerve of crude venom from the gastropod Conus striatus

Endean R., Williams H., Gyr P. and Surridge J. (1976) Some effects on muscle and nerve of crude venom from the gastropod Conus striatus. Toxicon, 14 4: 267-272. doi:10.1016/0041-0101(76)90022-2


Author Endean R.
Williams H.
Gyr P.
Surridge J.
Title Some effects on muscle and nerve of crude venom from the gastropod Conus striatus
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1976
Sub-type Article (original research)
DOI 10.1016/0041-0101(76)90022-2
Volume 14
Issue 4
Start page 267
End page 272
Total pages 6
Subject 3005 Toxicology
Abstract The venom of Conus striatus elicits spontaneous activity in nerves and in skeletal muscles. In frog sartorius muscle the venom lowers resting potentials of muscle fibres and triggers action potentials. The action potentials are of smaller amplitude and much longer duration than normal. Skeletal musculature and nerve ultimately become refractory to electrical stimulation if exposed to adequate concentrations of venom. Spontaneous twitches with amplitudes much greater than normal occur in isolated guinea-pig atria exposed to the venom. The venom has a spasmogenic action on the musculature of rat ilea which can be blocked by the 5-hydroxytryptamine antagonist 2-brom-d-lysergic acid diethylamide bitartrate. Active material in the venom is dialysable. The activity of the venom is modified by heating at 100°C. The pharmacological activity of the venom of C. striatus is similar to but not identical with that of the venom of the piscivorous species C. magus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 14 Jun 2016, 06:59:33 EST by System User