SERUM-FERRITIN IN DIAGNOSIS OF HÆMOCHROMATOSIS. A Study of 43 Families

Halliday J.W., Cowlishaw J.L., Russo A.M. and Powell L.W. (1977) SERUM-FERRITIN IN DIAGNOSIS OF HÆMOCHROMATOSIS. A Study of 43 Families. The Lancet, 310 8039: 621-624. doi:10.1016/S0140-6736(77)92495-3


Author Halliday J.W.
Cowlishaw J.L.
Russo A.M.
Powell L.W.
Title SERUM-FERRITIN IN DIAGNOSIS OF HÆMOCHROMATOSIS. A Study of 43 Families
Journal name The Lancet   Check publisher's open access policy
ISSN 0140-6736
Publication date 1977-09-24
Sub-type Article (original research)
DOI 10.1016/S0140-6736(77)92495-3
Volume 310
Issue 8039
Start page 621
End page 624
Total pages 4
Subject 2700 Medicine
Abstract 242 members of 43 families with idiopathic hæmochromatosis were investigated for increased body-iron stores in order to assess the value of serum-ferritin determination as a screening-test to detect preclinical disease. The serum-iron concentration was elevated in only 76% of relatives with increased iron stores, and it was also elevated in 10% of relatives with normal iron stores. The percentage saturation of transferrin was elevated in all relatives with increased iron stores but also in 33% of relatives with normal iron stores. Serum-ferritin was raised in 98% of relatives with increased iron stores and in only 3 (1.8%) of those with normal iron stores. These 3 subjects consumed alcohol in excess of 100 g ethanol per day, and their serum-ferritin levels fluctuated widely. Increased iron stores were reflected in increased serum-ferritin concentrations in subjects as young as 14 years in whom the liver-iron concentration was twice the normal upper limit and before there was any evidence of architectural damage to the liver. The serum-ferritin concentration is a useful non-invasive screening-test for precirrhotic hæmochromatosis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 14 Jun 2016, 06:11:03 EST by System User