A simplified kidney preservation system: Further development and results of extended perfusion

Hardie I.R., Clunie G.J.A., Balderson G., Leditschke J.F. and Leslie I.J. (1974) A simplified kidney preservation system: Further development and results of extended perfusion. Surgery, 75 5: 651-659.

Author Hardie I.R.
Clunie G.J.A.
Balderson G.
Leditschke J.F.
Leslie I.J.
Title A simplified kidney preservation system: Further development and results of extended perfusion
Journal name Surgery   Check publisher's open access policy
ISSN 0039-6060
Publication date 1974
Sub-type Article (original research)
Volume 75
Issue 5
Start page 651
End page 659
Total pages 9
Subject 2746 Surgery
Abstract Preliminary results with a greatly simplified continuous perfusion system indicated that satisfactory preservations of canine kidneys could be achieved in a small circuit from which much of the complexity required for pH, temperature, and pulse pressure control in conventional systems had been eliminated. Further development has been undertaken to simplify the pump control unit and to compare materials suitable for construction of the definitive circuit. Reliability of mechanical components and of preservation quality have been studied in a series of 48 hour perfusions of canine kidneys, with the use of both cryoprecipitated plasma and a five percent albumin solution as perfusates. Perfusions were carried out at both very low (0.5 °C.) and low (5 °C.) temperatures, since the operating temperature of the circuit, when immersed in chipped ice for simplified temperature control, depended on the material used in its construction. A total of 2,424 hours of perfusion was carried out, and no mechanical failure occurred; all components functioned efficiently and reliably. Plasma proved to be unsuitable at these low temperatures; only two of six dogs survived after 48 hours perfusion at 0.5 °C. and six of nine survived at 5 °C. All kidneys perfused with albumin at both temperatures survived, with maximum serum creatinines of 6.3 and 4.9 mg. percent, respectively, demonstrating that this solution is the more satisfactory of the two perfusates for this system.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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